![]() ![]() In prokaryotes, the leader sequences are usually short and at times contain an attenuator segment that is translated to a short-leader peptide. In eukaryotes, the leader sequence may vary from few nucleotides to more than 1000 nucleotides. They are involved in the regulation of gene expression in eukaryotes and prokaryotes. Leader sequences have the propensity for forming secondary structures (stem-loops) by base pairing of complementary sequences. This region is also known as the ‘five prime untranslated region’ ( Figure 1) of the mRNA. The region of a messenger RNA (mRNA) molecule that precedes the coding sequence of a gene is called the ‘leader sequence’. Samal, in Brenner's Encyclopedia of Genetics (Second Edition), 2013 Abstract ![]()
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